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采用红外光谱法(FTIR)、二阶导数红外光谱法和二维相关光谱分析技术(Two-dimensional correla-tion spectroscopy)研究不同配伍方式的大血藤、牡丹皮、赤芍水煎液的“宏观指纹特征”。结果表明,不同配伍方式的复方水煎液在3种谱图上均具有显著的变化规律。君药大血藤的特征峰1 610,1 518,1 446 cm-1为芳香物的特征峰,说明大血藤提取物中含有大量芳香类化合物,说明君药在原配伍中具有很好的溶出度,有效成分得以充分利用。不同比例的水煎剂中1 614 cm-1的特征峰倾向于大血藤1 610 cm-1,说明大血藤对水煎剂溶出物质影响较大。根据对特征峰的指认和归属,可揭示药物剂量的增减对复方整体配伍的影响。所提方法为中药复方配伍整体研究提供了新的途径。
The use of infrared spectroscopy (FTIR), second derivative infrared spectroscopy, and two-dimensional correla-tion spectroscopy to study the compatibility of different strains of Spatholobus suberectus, Cortex Moutan, and Radix Paeoniae Radix Decoction Macroscopic fingerprint characteristics." The results showed that the compound decoction of different compatibility methods had significant changes on the three kinds of spectra. The characteristic peaks of S. grandis, 1 610, 1 518, and 1 446 cm-1, were characteristic peaks of aromas, indicating that the extracts of Spatholobus subtilis contain large amounts of aromatic compounds, indicating that Junjun has good dissolution in the original compatibility. Degree, the active ingredients are fully utilized. The characteristic peaks of 1 614 cm-1 in different proportions of decoctions tend to be 1 610 cm-1, suggesting that Scutellaria can affect the dissolution of water decoction. According to the identification and attribution of characteristic peaks, it can reveal the influence of the increase or decrease of drug dose on the overall compatibility of the compound. The proposed method provides a new approach for the overall study of the compatibility of traditional Chinese medicines.