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目的:观察吉西他滨(国产)联合顺铂治疗晚期非小细胞肺癌的临床疗效和不良反应。方法:30例晚期非小细胞肺癌患者应用吉西他滨1.2/m2,第1、8天,静脉滴注0.5 h,顺铂50 mg,第1~3天静脉滴注,21 d为1个周期。结果:部分缓解(PR)12例,稳定(NC)10例,进展(PD)8例,有效率40%。不良反应为骨髓抑制和消化道症状。结论:国产吉西他滨联合顺铂治疗非小细胞肺癌是一个疗效好、毒性中等的一线方案。
Objective: To observe the clinical efficacy and adverse reactions of gemcitabine (domestic) combined with cisplatin in the treatment of advanced non-small cell lung cancer. Methods: 30 patients with advanced non-small cell lung cancer were treated with gemcitabine 1.2 / m2. On the first and eighth days, intravenous infusion of 0.5 mg cisplatin and 50 mg of cisplatin were given intravenously on days 1 to 3 for 21 days. Results: There were 12 cases of partial remission (PR), 10 cases of stable (NC) and 8 cases of progressive (PD). The effective rate was 40%. Adverse reactions to myelosuppression and gastrointestinal symptoms. Conclusion: The domestic gemcitabine combined with cisplatin in the treatment of non-small cell lung cancer is a first-line program with good curative effect and moderate toxicity.