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目的 了解严重急性呼吸综合征患者血清SARSIgG抗体检测结果及其临床意义。方法 对5 1例SARS患者恢复期血清SARSIgG抗体进行检测 ,按血清SARSIgG抗体检测结果对患者的临床资料进行分组 ,并对其进行回顾性比较分析。结果 2 7例SARSIgG抗体阳性 (5 2 .94 % ,2 7/ 5 1) ,其余 2 4例SARSIgG抗体阴性 (47.0 6 % ,2 4 / 5 1)。血清SARSIgG抗体阳性与阴性患者的年龄、发病天数、入院时体温进行比较 ,结果无显著性差异 ;而血清SARSIgG抗体阳性与阴性患者的发热天数、肺部炎症完全吸收天数、住院天数进行比较 ,结果有显著性差异 ;用Logistic回归做多因素分析 ,患者发热天数与血清SARSIgG抗体的产生密切相关。结论 SARS患者发热期间可能是SARS病毒刺激机体产生SARSIgG抗体最重要时期。在SARS患者恢复期期间采集血样 ,血清SARSIgG抗体检测结果阴性 ,临床可能仍不能排除SARS病毒的感染 ,临床和X线表现是诊断SARS的重要依据。
Objective To investigate the serum SARSIgG antibody in patients with severe acute respiratory syndrome and its clinical significance. Methods The serum SARSIgG antibodies in convalescent cases of 51 SARS patients were detected. The clinical data of SARSIgG antibodies were grouped according to the results of SARSIgG antibody test and analyzed retrospectively. RESULTS: Twenty-seven cases of SARSIgG antibodies were positive (52.94%, 27/51), and the other 24 cases were negative (47.0 6%, 24/51). Serum SARSIgG antibody positive and negative patients age, onset days, body temperature at admission were compared, the results were no significant difference; and serum SARSIgG antibody positive and negative days of fever, lung inflammation completely absorbed days, hospital days were compared, the results There was a significant difference; using Logistic regression multivariate analysis, the number of patients with fever and serum SARSIgG antibodies are closely related. Conclusion SARS virus may be the most important period for stimulating SARSIgG antibody production in SARS patients during fever. Blood samples were taken during the convalescence of SARS patients. Serum SARSIgG antibody test results were negative. Clinically, SARS virus infection may still not be ruled out. Clinical and X-ray findings are important basis for diagnosis of SARS.