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Alstonerine属于单萜吲哚生物碱,除其结构很有特征外,还报道对两株人肺癌细胞具有细胞毒性,因此,它自然就成为合成化学的重要目标.已经有多种合成策略用于构建这个结构体系:包括Pictet-Spengler反应和Dieckmann缩合反应、烯烃复分解关环反应、膦配体催化的[4+2]关环/Friedel-Craft环化、氮杂-Diels-Alder反应/分子内Heck反应、Pauson-Khand反应等.本工作根据构建环系的不同反应系统总结了Alstonerine的合成方法.大部分合成反应步骤较多,适合工业生产的有效合成方法还有待于进一步探索.
Alstonerine, which belongs to the monoterpeneindole alkaloid and is reported to be cytotoxic to two human lung cancer cells in addition to its structural features, has therefore naturally become an important target of synthetic chemistry.A variety of synthetic strategies have been used to construct This structure system includes Pictet-Spengler reaction and Dieckmann condensation reaction, olefine metathesis ring closure, phosphine ligand-catalyzed [4 + 2] ring closure / Friedel-Craft cyclization, aza-Diels-Alder reaction / intramolecular Heck Reaction, Pauson-Khand reaction, etc. In this work, Alstonerine synthesis method is summarized according to the different reaction systems of building ring system.Most of the synthetic reaction steps are more and effective synthesis methods suitable for industrial production have yet to be further explored.