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目的:探讨冠心病患者血浆白介素-35(IL-35)水平的变化与左室射血分数(LVEF)关系。方法:连续入选冠心病患者98例,其中稳定型心绞痛(SA)组(30例),不稳定型冠心病(UA)组(40例)和急性心肌梗死(AMI)组(28例)。同期冠脉造影正常的33例患者为对照组。采用夹心酶联免疫法(ELISA)测定血浆IL-35浓度。采用二维改良Simpson′s法测量LVEF。结果:与对照组相比,冠心病患者血浆IL-35水平显著降低,且UA组和AMI组血浆IL-35水平显著低于SA组。与对照组相比,SA组和AMI组LVEF显著降低。冠心病患者IL-35水平与LVEF显著正相关。结论:冠心病患者血浆IL-35水平可能与冠心病的发生及预后密切相关。
Objective: To investigate the relationship between plasma interleukin-35 (IL-35) and left ventricular ejection fraction (LVEF) in patients with coronary heart disease. Methods: A total of 98 consecutive patients with coronary heart disease (CAD) were enrolled in this study. The patients were divided into stable angina pectoris (SA) group (30 cases), unstable angina pectoris group (40 cases) and acute myocardial infarction group (28 cases). 33 cases of normal coronary angiography at the same period as the control group. Plasma IL-35 concentration was measured by sandwich enzyme-linked immunosorbent assay (ELISA). LVEF was measured using a two-dimensional modified Simpson’s method. Results: Compared with the control group, plasma IL-35 level was significantly lower in patients with coronary heart disease, and the levels of plasma IL-35 in UA group and AMI group were significantly lower than those in SA group. Compared with the control group, LVEF in SA group and AMI group decreased significantly. The level of IL-35 in patients with coronary heart disease was positively correlated with LVEF. Conclusion: Plasma IL-35 levels in patients with coronary heart disease may be closely related to the occurrence and prognosis of coronary heart disease.