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目的 探讨上皮钙粘附素 (E cd)及其相关蛋白连接素 (catenin)在胃癌中的表达及其意义。方法 应用免疫组织化学S P法检测E cd及catenin在 6 0例胃癌中的表达。结果 在各型胃癌中 ,E cd/catenin复合物 1项以上的成分表达异常高达83 .3 % (5 0 /6 0 )。E cd、α catenin表达与胃癌的浸润深度、Lauren′s分型密切相关 (P <0 .0 1) ,与淋巴结转移无关 (P >0 .0 5 ) ;而 β catenin表达与胃癌的浸润深度和Lauren′s分型无关 (P >0 .0 5 ) ,但与淋巴结转移有关 (P <0 .0 5 ) ;E cd、β catenin表达阳性者 3年生存率明显好于阴性表达者。结论 E cd/catenin复合物染色异常在胃癌中极其常见 ,它们与胃癌的临床病理学不同特征密切相关 ,可作为评价胃癌生物学特性的较好指标。
Objective To investigate the expression of E cadherin (E cd) and its related protein catenin in gastric cancer and its significance. Methods Immunohistochemical SP method was used to detect the expression of E cd and catenin in 60 cases of gastric cancer. Results In all kinds of gastric cancer, the expression of more than one component of E cd / catenin complex was as high as 83.3% (50/60). E cd, α catenin expression and gastric cancer depth of invasion, Lauren’s classification is closely related (P <0.01), and has nothing to do lymph node metastasis (P> 0.05); and β catenin expression and depth of invasion of gastric cancer (P <0.05), but had no correlation with Lauren’s classification (P> 0.05), but it was related to lymph node metastasis (P <0.05). The 3-year survival rate of E cd and β catenin expression was significantly better than that of negative expression. Conclusion E cd / catenin complex abnormalities are extremely common in gastric cancer. They are closely related to different clinical and pathological features of gastric cancer and may be used as a good indicator to evaluate the biological characteristics of gastric cancer.