论文部分内容阅读
[目的]研究肝康膏对四氯化碳所致小鼠急性肝损伤的保护作用.[方法]用四氯化碳建立小鼠急性肝损伤模型,肝康膏大、中、小剂量组小鼠灌胃给予2.00,1.00,0.50g/kg肝康膏提取物,用比色分析法测定血清丙氨酸氨基转移酶(ALT)活性及肝组织超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)活性和丙二醛(MDA)含量.[结果]肝康膏大、中、小剂量组血清ALT活性和肝组织MDA含量与模型对照组比较显著降低(P<0.01),肝组织SOD和GSH-Px活性明显升高(P<0.01,P<0.05).[结论]肝康膏对四氯化碳所致小鼠急性肝损伤具有一定的保护作用.
[Objective] To study the protective effect of Gankang cream on carbon tetrachloride-induced acute liver injury in mice. [Methods] Acute liver injury model was established in mice with carbon tetrachloride. The rats were intragastrically given 2.00,1.00,0.50g / kg Gan Kang extract, and the activity of serum alanine aminotransferase (ALT) and the activity of superoxide dismutase (SOD) and glutathione (GSH-Px) activity and malondialdehyde (MDA) content. [Results] The serum ALT activity and liver MDA content of liver, liver, kidney and liver were significantly decreased compared with the model control group <0.01), and the activities of SOD and GSH-Px in liver tissue were significantly increased (P <0.01, P <0.05). [Conclusion] Ganghuangao can protect mice from acute liver injury induced by carbon tetrachloride.