论文部分内容阅读
本文报道￣９９ｍＴｃ－新半乳糖白蛋白（￣９９ｍＴｃ－ＮＧＡ）与大鼠肝细胞膜进行体外结合试验。结果表明：￣９９ｍＴｃ－ＮＧＡ系与肝细胞膜上的高亲和力低容量（Ｋ＿１：８．４０８９×１０￣９Ｌ／ｍｏｌ；Ｒ＿１：１．７３５０×１０￣（－１２）ｍｏｌ／ｍｇ）和低亲和力高容量（Ｋ＿２：２．０８２７×１０￣８Ｌ／ｍｏｌ；Ｒ＿２：６．９５３０×１０￣（－１２）ｍｏｌ／ｍｇ）２个结合位点相结合，其结合表现出高特异性、可饱和性及对细胞膜蛋白浓度的线性依赖性，具备受体介导结合的基本特征。￣（９９ｍ）Ｔｃ－ＮＧＡ是一个很有希望的肝受体显像剂。
This paper reports ~ 99mTc-neo-galactose albumin (~ 99mTc-NGA) and rat liver cell membrane in vitro binding assay. The results showed that: ~ 99mTc-NGA line with high affinity and low capacity of the liver cell membrane (K_1: 8.4089 × 10 ~ 9L / mol; R_1: 1.7350 × 10 ~ (-12) mol / mg) and low affinity (K_2: 2.0827 × 10 ~ 8L / mol; R_2: 6.9530 × 10 ~ (-12) mol / mg), which showed high specificity and saturability Linear dependence on cell membrane protein concentration, with the basic characteristics of receptor-mediated binding. ¯ (99m) Tc-NGA is a promising hepatic receptor imaging agent.