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人肾炎时免疫复合物主要沉积在肾小球系膜上。实验证明肾小球系膜(以下简称系膜)具有转移和处理某些大分子物的功能。据认为这对于某些肾小球肾炎的病理变化及其予后起着关键性作用。因此关于肾炎机制的探讨使系膜成为一个非常活跃的研究领域。国外已有多篇有关问题的综述;国内丁荣施于1981年较全面地介绍了国外有关的研究进展。近几年关于系膜的研究更加深入并有了很大的发展。本文仅就某些大分子物沉积所引起的肾小球系膜的病理变化以及系膜内大分子物的归宿问题概要地综合介绍。一、系膜和基膜的关系肾小球基膜是由毛细血管内皮和足细胞上皮的基膜融合而成,在电镜下可区分为内、中
Immune complexes in human nephritis are mainly deposited on the glomerular mesangium. Experiments show that the glomerular mesangial (hereinafter referred to as mesangial) has the function of transferring and handling certain macromolecules. This is believed to play a key role in the pathological changes of some glomerulonephritis and its prognosis. So on the mechanism of nephritis makes the mesangial become a very active area of research. There are many foreign countries have reviewed the issue; domestic Ding Rongshu in 1981 a more comprehensive introduction to foreign research progress. In recent years, researches on mesangial have been more in-depth and have made great progress. This article only summarizes the pathological changes of mesangial membrane caused by the deposition of certain macromolecules and the fate of macromolecules in mesangium. First, the relationship between mesangial and basement membrane glomerular basement membrane is composed of capillary endothelial cells and podocyte epithelial basement membrane fusion formed under the electron microscope can be divided into, in