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目的探讨放射性125I粒子植入联合高频热疗治疗晚期肺癌的临床效果。方法将216例晚期肺癌患者随机分为研究组和对照组各108例。对照组采用单纯热疗,研究组采用放射性粒子125I植入加高频热疗。比较2组近期肿瘤控制率、胸痛改善率及不良反应发生情况。结果研究组患者近期肿瘤控制率、胸痛改善率均高于对照组(P<0.05)。2组不良反应发生率差异无统计学意义(P>0.05)。结论放射性125I粒子植入联合高频热疗治疗晚期肺癌,能提高近期肿瘤控制率和胸痛改善率,2组不良反应均较轻,值得推广应用。
Objective To investigate the clinical effect of radioactive 125I seed implantation combined with high frequency hyperthermia in the treatment of advanced lung cancer. Methods 216 patients with advanced lung cancer were randomly divided into study group and control group of 108 cases. The control group was treated with hyperthermia alone. The study group was treated with 125I radioactive particles plus high frequency hyperthermia. Compare the recent two groups of tumor control rate, chest pain improvement rate and adverse reactions. Results The tumor control rate and the improvement rate of chest pain in study group were higher than those in control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusions Radioactive 125I seed implantation combined with high frequency hyperthermia in the treatment of advanced lung cancer can improve the rate of tumor control and chest pain improvement in the near future. The adverse reactions in the two groups are mild and should be popularized and applied.