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测定染尘不同时间大鼠支气管肺泡灌洗液中细胞代谢活性、溶菌酶和总蛋白含量等细胞毒作用与全肺组织干重、全肺胶原蛋白含量及肺组织病理学改变等致纤维化作用。结果表明,多数矿物粉尘对肺内细胞的毒性作用及致肺纤维化作用与粉尘中所含游离SiO_2的量有密切的相关性;复合粉尘或混合性粉尘所致生物学危害作用并不是单一粉尘或组分作用的简单加合。
The cytotoxicity, the cytotoxicity of lysozyme and total protein in bronchoalveolar lavage fluid and the cytotoxicity of whole lung tissue, the content of collagen in the whole lung and the pathological changes of the lung tissue in different time periods . The results showed that most of the toxic effects of mineral dust on lung cells and pulmonary fibrosis caused by the role of the amount of free SiO2 contained in the dust is closely related to the biological hazards caused by composite dust or mixed dust is not a single dust Or simple addition of the components.