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本文就近几年来C反应蛋白 (CRP)作为急性冠状动脉综合征 (ACS)的预测因子等方面做了如下综述。慢性炎症是动脉粥样硬化发生发展的重要机制 ,主要由致炎因子造成血管内皮损伤而引发的一系列与免疫反应有关的炎症和纤维增生反应。CRP从其功能、特征来看与炎症反应关系密切 ,与冠心病的严重程度及意外事件的发生呈正相关 ,因而可作为预测因子 ,并可预示其冠状动脉病变的不稳定性。在CRP对影响机制的研究方面 ,目前认为主要与免疫的炎性反应有关。
This review summarizes the recent progress of C-reactive protein (CRP) as a predictor of acute coronary syndrome (ACS). Chronic inflammation is an important mechanism of the development of atherosclerosis, which is mainly caused by a series of immune response-related inflammation and fibrogenesis induced by inflammatory factor-induced vascular endothelial injury. CRP is closely related to the inflammatory response in terms of its function and characteristics, and is positively correlated with the severity of coronary heart disease and the occurrence of unexpected events. Therefore, CRP can be used as a predictor and can predict the instability of coronary artery disease. At present, CRP is mainly concerned with the immune inflammatory response in the study of the mechanism of CRP.