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目的探讨慢性乙型肝炎(CHB)患者接受核苷(酸)类似药物治疗过程中护理要点。方法将152例CHB患者分为住院抗病毒治疗组(76例),门诊抗病毒治疗组(76例),治疗方案均采用常规护肝治疗的基础上加用核苷(酸)类似药物抗病毒治疗,同时对住院组患者进行心理护理、健康教育及服用核苷(酸)类似药物注意事项的健康宣教,总结护理要点。结果通过96周的治疗和随访,住院组中出现病毒变异或病毒突破者累计6例,门诊组中出现病毒变异或突破者累计10例,在抗病毒治疗16周时住院抗病毒组和门诊抗病毒组的血清HBV DNA转阴率(<103copies/ml)分别为92.11%、64.47%,两组差异有统计学意义(χ2=18.54,P<0.05)。结论核苷(酸)类似药物治疗CHB患者,在治疗过程中疾病及药物知识的宣教、心理护理,健康教育及强化患者的遵医行为,及时观察并处理病情的变化,是治疗成功的关键。
Objective To investigate the nursing points in patients with chronic hepatitis B (CHB) receiving nucleoside (acid) -like drugs. Methods A total of 152 patients with CHB were divided into two groups: hospitalized antiviral therapy group (76 cases) and outpatient antiviral therapy group (76 cases). The treatment regimens were all treated with conventional hepatoprotective therapy plus nucleoside (acid) -like drugs At the same time, we should carry out mental health care, health education and healthy missionary education for the inpatients taking the precautions of nucleoside (acid) -like drugs, and summarize the nursing points. Results After 96 weeks of treatment and follow-up, there were 6 cases of virus mutation or virus breakthrough in the inpatient group, 10 cases of virus mutation or breakthrough in the outpatient group, inpatient antiviral group and outpatient anti-viral group at 16 weeks after anti-virus treatment The serum HBV DNA negative rates (<103copies / ml) in the virus group were 92.11% and 64.47%, respectively, with significant difference between the two groups (χ2 = 18.54, P <0.05). Conclusions It is the key to the successful treatment of patients with CHB that similar nucleoside (acid) drugs are used to treat the disease and drug knowledge during the course of treatment. Psychological nursing, health education and patient compliance should be observed and treated timely.