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目的探讨冠状动脉粥样硬化性心脏病冠状动脉造影(coronary angiography,CAG)患者冠状动脉病变的严重程度与胆红素水平的相关性。方法选择2015年1月—2016年1月在本院行CAG检查的患者157例,分为行经皮冠状动脉支架植入术(percutaneous coronary artery stent implantaition,PCI)组和对照组,其中PCI组为CAG阳性患者并经PCI共127例,对照组为CAG阴性患者共30例。积分运用美国心脏协会制定的Gensini积分法,采用Seldinger技术进行CAG评估冠状动脉病情,根据CAG结果将其分为单支的病变、双支的病变和三支的病变。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果对照组Tbil、Dbil、Ibil水平分别为(12.4±3.4)、(3.0±1.2)、(9.4±2.1)μmol/L,病例组Tbil、Dbil、Ibil水平分别为(10.2±3.1)、(2.3±1.5)、(7.9±2.4)μmol/L,对照组和PCI组Tbil、Dbil、Ibil之间对比差异均有统计学意义(均P<0.05)。不同胆红素水平组的病变支数分布对比差异有统计学意义(P<0.05)。总胆红素水平与Gensini积分呈负相关(r=-0.330)。结论冠心病PCI组患者胆红素水平偏低,胆红素水平可能与冠状动脉病变的支数和病变严重程度相关。
Objective To investigate the relationship between severity of coronary lesions and bilirubin in coronary angiography (CAG) patients with coronary atherosclerotic heart disease. Methods A total of 157 patients underwent CAG in our hospital from January 2015 to January 2016 were divided into control group and percutaneous coronary artery stent implantation (PCI) group. The PCI group was CAG-positive patients and by PCI a total of 127 cases, the control group of CAG-negative patients a total of 30 cases. Points using Gensini integral method developed by the American Heart Association, the use of Seldinger CAG assessment of coronary artery disease, according to CAG results were divided into single lesions, double lesions and three lesions. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The levels of Tbil, Dbil and Ibil in the control group were (12.4 ± 3.4), (3.0 ± 1.2) and (9.4 ± 2.1) μmol / L, respectively. The levels of Tbil, ± 1.5) and (7.9 ± 2.4) μmol / L, respectively. There was significant difference between Tbil, Dbil and Ibil in control group and PCI group (all P <0.05). The distributions of lesions in different bilirubin groups showed statistically significant differences (P <0.05). Total bilirubin levels were negatively correlated with Gensini scores (r = -0.330). Conclusion The serum bilirubin in CAD patients with coronary heart disease is low, and the bilirubin level may be related to the number of coronary lesions and the severity of the disease.