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目的:了解我院严重药品不良反应(ADR)发生的特点和规律,促进临床安全、合理用药。方法:对我院2010、2011年103例严重ADR报告,分别从患者的性别、年龄、给药途径、药品种类及临床表现等方面进行统计分析。结果:103例严重ADR报告中,新的严重ADR有10例(9.71%);中枢神经系统用药占绝大多数为94例(89.52%),其中抗精神病药占71例;临床表现涉及肝胆系统的最多占62例(56.36%)。结论:应重视严重ADR监测和报告,加强临床合理用药,尽量减少严重ADR的发生。
Objective: To understand the characteristics and laws of serious adverse drug reaction (ADR) in our hospital and to promote clinical safety and rational drug use. Methods: A total of 103 cases of severe ADR in our hospital from 2010 to 2011 were analyzed statistically from the patient’s gender, age, route of administration, type of drug and clinical manifestations. Results: Among the 103 cases of serious ADR, 10 cases (9.71%) were serious new ADRs, 94 cases (89.52%) were central nervous system, 71 cases were antipsychotics. The clinical manifestations involved hepatobiliary system Up to 62 cases (56.36%). Conclusion: We should pay attention to the monitoring and reporting of severe ADR, strengthen clinical rational use of drugs, and minimize the occurrence of severe ADR.