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目的:研究高压氧辅助治疗在子宫切口妊娠术后出血中的应用，并分析其对凝血功能的影响。方法:选取2016年1月至2018年12月浙江萧山医院妇科收治的68例子宫切口妊娠患者作为研究对象，随机数字表法分为对照组和观察组，每组34例。对照组患者给予聚桂醇局部硬化后行清宫取胚术，观察组在对照组基础上联合高压氧辅助治疗，比较2组患者术后出血、凝血功能及D-二聚体变化，同时比较2组患者不良反应发生情况。结果:对照组和观察组患者术后48 h内出血量分别为(37.24±4.51) ml和(34.13±4.04) ml，差异无统计学意义(n P>0.05)。治疗后，2组患者凝血功能均有改善，且观察组患者纤维蛋白原(fibrinogen, FIB)及D-二聚体水平较对照组升高，凝血酶原时间(prothrombin time, PT)、活化部分凝血活酶时间(activated partial thromboplastin time, APTT)、抗凝血酶(antithrombin, AT)水平及人绒毛膜促性腺激素(β-hCG)则明显降低，差异均有统计学意义(n P<0.05)。观察组患者发生头晕头痛1例(2.94%)、恶心呕吐2例(5.88%)、腹痛1例(2.94%)、发热0例，不良反应发生率均低于对照组，其中头晕头痛不良反应发生率差异有统计学意义(n P0.05). After treatment, the blood coagulation function of both groups improved, and the fibrinogen (FIB) and D-dimer levels of the patients in the observation group were significantly higher than those in the control group. However, prothrombin time (PT), activated partial thromboplastin time (APTT), antithrombin (AT) level, and human chorionic gonadotropin (β-hCG) were significantly reduced with statistically significant differences(n P<0.05). There was 1 patient with dizziness headache (2.94%), 2 patients with nausea and vomiting (5.88%), 1 patient with abdominal pain (2.94%), and no patient with fever in the observation group, and the occurrence of adverse reactions was lower than that of the control group. The difference between the two groups regarding the occurrence of dizziness and headache was statistically significant (n P<0.05).n Conclusion:Hyperbaric oxygen treatment can significantly increase the FIB and D-dimmer levels of patients with cesarean scar pregnancy, reduce their PT, APTT and AT, and effectively improve the blood coagulation function, which is helpful to prevent postoperative bleeding, as well as reduce the occurrence of adverse reactions.