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对于急性冠状动脉综合征患者的治疗,除非有高出血风险,氯吡格雷应联合阿司匹林使用至少1年。但有部分患者停用氯吡格雷后发生的心血管不良事件,一些研究认为此现象与停用氯吡格雷后血小板功能反跳有关。在此对停用氯吡格雷后血小板聚集率增加的定义,血小板功能反跳现象与血小板聚集能力、炎性因子等之间的关系及延长使用或逐渐停用氯吡格雷能否预防此反跳现象的发生予以综述。
For patients with acute coronary syndromes, clopidogrel should be given in combination with aspirin for at least 1 year unless there is a high risk of bleeding. However, some patients have discontinued clopidogrel after cardiovascular adverse events, some studies suggest that this phenomenon and the withdrawal of clopidogrel after platelet function rebound related. Here we define the definition of an increase in platelet aggregation after the discontinuation of clopidogrel, the relationship between platelet function rebound phenomenon and platelet aggregation ability, inflammatory factors and the like, and whether prolonged use or gradual discontinuation of clopidogrel can prevent this rebound The occurrence of the phenomenon to be reviewed.