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目的 研究腹腔大容积化疗预防大肠癌术后腹腔复发及肝转移的效果。方法 自 1995年 6月～ 1999年 12月将大肠癌术后患者分成 2组 :A组 5 5例采用经埋藏式化疗泵行大容积腹腔化疗 ,B组 43例行常规静脉化疗 (CF/ 5 Fu方案 ) ,比较两者术后肝及腹腔复发的发生率、发生时间及术后存活时间。结果 A组 5 5例中 ,有 2例于术后 9、15个月出现腹腔复发 ,2例于术后13、16个月出现肝转移 ,发生率为 8.3 % ,5 1例 (92 .7% )未见转移 ,平均存活时间为 32个月。B组术后 3～ 14个月分别有 5例出现肝转移和 6例出现腹腔复发 ,发生率为 2 5 .6 % ,32例 (74.4% )未见转移 ,平均存活时间为 2 0个月。结论 早期腹腔大容积化疗预防大肠癌术后腹腔内复发、肝转移有明显的疗效 ,且方法安全、简单、实用。
Objective To study the effect of intraperitoneal large volume chemotherapy in prevention of peritoneal recurrence and liver metastasis after operation of colorectal cancer. Methods From June 1995 to December 1999, the patients with colorectal cancer were divided into two groups: 55 cases in group A received large-volume intraperitoneal chemotherapy via buried chemotherapy pump, 43 cases in group B received routine intravenous chemotherapy (CF / 5 Fu program) to compare the incidence of postoperative liver and abdominal recurrence, the time of occurrence and postoperative survival time. Results Among 5 5 cases in group A, 2 cases developed intraperitoneal recurrence at 9 and 15 months postoperatively, and 2 cases showed hepatic metastases at 13 and 16 months postoperatively, with an incidence of 8.3% and 51 cases (92.7% %) No metastasis, the average survival time of 32 months. In group B, 5 cases of liver metastases and 6 cases of abdominal recurrence occurred in 3 to 14 months after operation, respectively, with a rate of 25.6% and 32 cases (74.4%) without metastasis. The average survival time was 20 months . Conclusion Early peritoneal chemotherapy to prevent postoperative intraperitoneal recurrence of colorectal cancer, liver metastases have a significant effect, and the method is safe, simple and practical.