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应用吡啶斯的明(PD)对15例正常儿童和16例生长激素(GH)缺乏症病儿进行GH激发试验,用放射免疫法测定GH.结果发现正常儿童服PD后GH明显升高,于60～90min达峰值.服药后60min GH显著高于左旋多巴试验(P<0.01),90min显著高于克罗宁试验(P<0.05).16例GH缺乏症病儿12例(75%)对PD无反应,4例(25%)出现GH升高,峰值超过5μg/L,与这些病例克罗宁和左旋多巴试验比较差异有极显著意义(P<0.01).提示PD试验是一项简单有效的GH激发试验,PD可能对某些GH缺乏症病儿有治疗价值.
GH provocation test was performed in 15 normal children and 16 patients with growth hormone deficiency (GH) deficiency by pyridostigmine (PD), and GH was measured by radioimmunoassay.It was found that GH was significantly increased in normal children after PD (P <0.01), GH at 90 min was significantly higher than that of Cronin (P <0.05) .Among the 16 GH patients, 12 (75% There was no response to PD, GH increased in 4 patients (25%) and the peak value exceeded 5μg / L, which was significantly different from those in Cronin and Levodopa (P <0.01) Simple and effective GH provocation test, PD may have therapeutic value in children with certain GH deficiency.