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采取因职业而接触乙烯类或苯类诱变剂的孕妇静脉血和其新生儿脐带血进行SCE和MN测定,发现接触两类诱变剂的母血SCE分别为8.55±0.84和9.44±1.12,均高于对照组母血SCE(7.68±1.40);而微核率分别为0.833‰和0.75‰也高于对照组母血微核率(0.267‰);接触两类诱变剂的脐血SCE分别为8.44±1.43和8.75±0.88,均高于对照组脐血SCE(6.71±1.27);而微核率分别为0.727‰和0.818‰,也分别高于对照组脐血微核率。结果还表明母亲被动吸烟增强了化学诱变剂对新生儿的遗传毒性作用。本研究首次发现乙烯类诱变剂对新生儿具有遗传危害。
SCE and MN measurements of venous blood of pregnant women and umbilical cord blood of their newborns exposed to occupational exposure to ethylene or benzene mutagens found that the SCEs of maternal blood exposed to both mutagens were 8.55 ± 0.84 and 9.44 ± 1.12, (7.68 ± 1.40), while the micronuclei rates were 0.833 ‰ and 0.75 ‰, respectively, which were also higher than those of the control group (0.267 ‰). The cord blood SCE exposed to two kinds of mutagens (8.44 ± 1.43 and 8.75 ± 0.88 respectively), which were higher than that of the control group (6.71 ± 1.27). The micronucleus rates were 0.727 ‰ and 0.818 ‰, respectively, which were also higher than that of the control group. The results also show that mothers passive smoking increases the genotoxic effects of chemical mutagens on newborns. This study found for the first time that ethylene mutagens have a genetic risk to newborns.