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目的探讨阿托伐他汀和辛伐他汀治疗颈动脉斑块的效果,指导临床治疗对药物的选择。方法选择我院2005年1月-2009年12月经彩色多普勒检查发现颈动脉斑块患者84例,男32例,女52例,年龄38-75岁。将84例患者随机分成A、B两组,每组42例。A组口服阿托伐他汀10mg/d,B组口服辛伐他汀20mg/d。于治疗前、治疗6、12个月用彩色多普勒超声测量两组病例颈总动脉后壁中-内膜厚度(IMT)及双侧颈总动脉、颈内动脉和颈外动脉粥样斑块的数量、类型。结果 A组治疗6个月后,B组治疗治疗12个月后IMT减少,与治疗前比较,差异有统计学意义(P<0.05);治疗12个月后,A组斑块减少数量优于B组,A组扁平斑、硬斑的消退作用优于B组(P<0.05)。结论阿托伐他汀和辛伐他汀对颈动脉斑块均具有治疗作用;阿托伐他汀产生作用早,减少斑块的效果优于辛伐他汀。
Objective To investigate the effect of atorvastatin and simvastatin on carotid artery plaque and to guide the choice of drugs for clinical treatment. Methods 84 cases of carotid plaque were found in our hospital from January 2005 to December 2009 by color Doppler examination. There were 32 males and 52 females, aged 38-75 years old. 84 patients were randomly divided into A, B two groups, each group 42 cases. Group A received atorvastatin 10 mg / d, Group B received simvastatin 20 mg / d. Before treatment, the IMT and the common carotid artery, internal carotid artery and external carotid artery atherosclerotic plaques in the two groups were measured by color Doppler ultrasound at 6 and 12 months after treatment. The number of blocks, type. Results After 6 months of treatment in group A, the IMT decreased after 12 months of treatment in group B, which was significantly different from that before treatment (P <0.05). After 12 months of treatment, the number of plaque reduction in group A was superior to In group B, the flattening of plaque and hard spot in group A was better than that in group B (P <0.05). Conclusions Both atorvastatin and simvastatin have therapeutic effects on carotid plaque. Atorvastatin has earlier effect and plaque reduction than simvastatin.