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采用 2 取代 5 氟 3H 4 嘧啶酮与芳酰氯在丙酮中于三乙胺存在下反应 ,合成了 17个 2 取代 3 芳酰基 5 氟 4 嘧啶酮类化合物 .目标化合物的结构经IR、1H NMR、元素分析或MS确定 ,初步生物活性测定显示 ,部分化合物具有一定的抗肿瘤活性
The 17 2-substituted 3-aroyl 5-fluoro 4-pyrimidinones were synthesized by the reaction of 2-substituted 5-fluoro-3H 4 -pyrimidinone and aroyl chloride in acetone in the presence of triethylamine.The structures of the target compounds were characterized by IR, 1H NMR, Elemental analysis or MS determination, preliminary bioassay showed that some compounds have some anti-tumor activity