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制备了一种稳定性和重现性均良好的新型PVC膜涂丝诺氟沙星选择电极 ,该电极是以Ag/AgCl丝为基体 ,在其表面先涂一层含Cl-的脲醛树脂 ,然后再涂一层含硅钨酸 -诺氟沙星离子缔合物的PVC膜。采用正交设计法 ,研究了离子缔合物的种类、活性物在膜中的含量及增塑剂3因素对电极的影响。电极的线性范围为7.9×10 -5～1.0×10 -2mol·L -1 ,检出限为2.5×10 -5mol·L -1,斜率为35.7mV/decade(30℃) ,可直接用于诺氟沙星胶囊的含量测定 ,回收率为99 %～102 % ,结果与中国药典法基本一致。
A novel PVC membrane coated Norfloxacin electrode with good stability and reproducibility was prepared. The electrode was prepared by coating Ag / AgCl wire with a layer of urea-formaldehyde resin on its surface, Then apply a layer of PVC film containing silicotungstic acid-norfloxacin ion association. The orthogonal design method was used to study the types of ion-association compounds, the content of active compounds in the membrane and the influence of plasticizer on the electrode. The linear range of the electrode was from 7.9 × 10 -5 to 1.0 × 10 -2 mol·L -1 with a detection limit of 2.5 × 10 -5 mol·L -1 and a slope of 35.7 mV / decade (30 ° C) Determination of norfloxacin capsules, the recovery rate of 99% to 102%, the results are basically the same with the Chinese Pharmacopoeia.