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目的 了解远航对海员免疫功能的影响。方法 采集 45名远航海员的血样 ,测定体液免疫指标 IL-4、IL-6和免疫球蛋白 Ig A、Ig M、Ig G;细胞免疫指标 IL-2、IFN-r;非特异性免疫指标 IL-1 2、TNF-α。分组观察上述指标航行前、后的变化。结果 (1 )体液免疫 :IL -4、IL -6航后比航前降低非常显著(P<0 .0 1 ) ;航后免疫球蛋白 Ig A、Ig M升高显著 (P<0 .0 5) ;(2 )细胞免疫 :IL-2航后较航前升高非常显著 (P<0 .0 1 ) ;(3 )非特异性免疫 :TNF-α航后较航前升高非常显著 (P<0 .0 1 )。结论 远航对海员免疫功能有一定影响 ,但均在正常生理范围内
Objective To understand the impact of voyage on the immune function of seafarers. Methods The blood samples of 45 voyage pilots were collected for determination of humoral immunity indicators IL-4, IL-6 and immunoglobulin Ig A, Ig M, Ig G; cellular immunity indicators IL-2 and IFN-γ; non-specific immune indicators IL- 1 2, TNF-α. Subgroup observation of these indicators before and after changes in navigation. Results (1) Humoral immunity: The IL-4 and IL-6 decreased significantly after flight compared with that before flight (P <0.01); IgA and IgM increased significantly after flight (P <0. 0 5); (2) Cellular immunity: The IL-2 level was significantly higher than that before flight (P <0.01). (3) Non-specific immunity: TNF- P <0 .0 1). Conclusion Voyage has certain influence on the immune function of seafarers, but all are within the normal physiological range