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目的 探讨绝经后妇女血清调钙激素水平对骨形成、骨吸收及骨密度的影响。方法 142名健康绝经后妇女测定血雌二醇 (E2 )、睾酮 (T)、总三碘甲状腺原氨酸 (TT3)、总甲状腺素(TT4)、甲状旁腺激素全段 (PTH SP)、降钙素 (CT)、骨钙素 (BGP)、尿脱氧吡啶啉 (DPD)、尿肌酐 (Cr)。双能X线骨密度仪测定腰椎、髋部、前臂骨密度 (BMD) ,对检测结果进行分析。结果 本组骨质疏松患病率为 6 0 48% ,低骨量 32 39% ,正常骨量 7 13 %。血清 6种调钙激素中T、E2、TT3、TT4、CT与BMD、BGP呈正相关 ,与年龄负相关 ;PTH SP与BMD呈负相关 ,与年龄、DPD Cr呈正相关。结论 绝经后妇女血调钙激素水平影响骨形成、骨吸收和骨密度 ,使骨代谢趋向于负平衡 ,是绝经后妇女易发生骨质疏松症的重要原因
Objective To investigate the effect of serum calmodulin on bone formation, bone resorption and bone mineral density in postmenopausal women. Methods Serum levels of E2, T, TT3, TT4 and PTH SP were measured in 142 healthy postmenopausal women. Calcitonin (CT), osteocalcin (BGP), urine deoxypyridinoline (DPD), urinary creatinine (Cr). Bone mineral density measurement of lumbar spine, hip, forearm bone mineral density (BMD), the test results were analyzed. Results The prevalence of osteoporosis in this group was 60%, low bone mass 32 39%, and normal bone mass 73%. There was a positive correlation between T, E2, TT3, TT4, CT and BMD, BGP in serum and negative correlation with age. PTH SP was negatively correlated with BMD and positively correlated with age and DPD Cr. CONCLUSIONS: The blood levels of calmodulin in postmenopausal women influence bone formation, bone resorption and bone mineral density, leading to a negative balance in bone metabolism, which is an important reason for postmenopausal women prone to osteoporosis