目的:建立沙利度胺的含量测定方法。方法:不经消化氮测定法。结果:沙利度胺在0.2030~0.6153g范围内,取量与其消耗硫酸滴定液(0.05mol/L)的毫升数呈良好的线性关系,相关系数r=1.0000(n=5)。方法平均回收率为99.97％(RSD=0.22％,n=9)。结论:实验结果表明,本方法简便、快速、准确。可用于测定沙利度胺的含量。 Objective: To establish a method for the determination of thalidomide. Method: Not digested nitrogen determination. Results: Thalidomide was in the range of 0.2030-0.6153g, and the linear relationship was obtained with the milliliter of sulfuric acid titration solution (0.05mol / L). The correlation coefficient was 1.0000 (n = 5). The average recovery was 99.97% (RSD = 0.22%, n = 9). Conclusion: The experimental results show that this method is simple, rapid and accurate. Thalidomide can be used to determine the content.