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目的调查千金藤素对矽肺患者的免疫功能是否有调节作用。方法采用自身前后对照实验。疗程及服法:1年为1个疗程,全年服43周,每日120～240mg分1～3次口服,连服5个月,每周给药6天,休息1天,间隙1个月不服药,再连服5个月,休息1个月为1个疗程。结果服用千金藤素1个疗程后,可疑矽肺(0+)、矽肺患者感冒次数以及咳痰、胸闷、乏力症状较用药前减少(P<0.05)。2组非特异性免疫指标(IgA)都明显增高,0+用药前(1.75±0.62)g/L,1个疗程后(2.12±0.61)g/L,P<0.05;≥I期矽肺用药前(1.45±0.75)g/L,1个疗程后(2.38±0.40)g/L,P<0.05。类风湿因子(RF)阳性率明显降低(用药前10例矽肺RF为阳性,其中7例规范用药1个疗程后均为阴性)。结论千金藤素具有增强矽肺患者免疫力的作用。
Objective To investigate whether cepharanthine can modulate the immune function of patients with silicosis. Methods using its own control before and after the experiment. Treatment and service method: 1 year for a course of treatment, the annual service 43 weeks, daily 120 ~ 240mg 1 to 3 times orally, even for 5 months, 6 days a week, 1 day off, a gap of 1 Months without medication, and then take 5 months, 1 month rest for a course of treatment. Results After treated with cepharanthine for one course, the number of colds, sputum, chest tightness and weakness in patients with suspected silicosis (0+), silicosis decreased compared with those before treatment (P <0.05). The levels of IgA in the two groups were significantly increased (P <0.05) before 0 + pretreatment (1.75 ± 0.62) g / L, after one course of treatment (P <0.05) 1.45 ± 0.75) g / L, after one course of treatment (2.38 ± 0.40) g / L, P <0.05. The positive rate of rheumatoid factor (RF) was significantly lower (RF was positive in 10 cases of silicosis before treatment, 7 cases were negative after one course of standard medication). Conclusion Cepharanthine has the effect of enhancing the immunity of silicosis patients.