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抗菌肽是生物体内组成性或诱导性表达的一类小分子多肽,是机体防御系统的重要组成部分。抗菌肽不仅具有广谱杀菌能力,还具有抗真菌、抗病毒、抗寄生虫等生物活性。抗菌肽体外的抗炎作用已经研究较多,但其在体内的抗炎作用才逐渐引起学者的关注。抗菌肽对炎症的调节是多方面的,主要通过抑制生物性致炎因子的生长、调节炎症相关信号通路及其转录因子的表达、调节免疫活性以及中和LPS等,从而发挥抗炎作用。本文就抗菌肽在体内抗炎作用的研究进展作一综述。
Antibacterial peptides are constitutive or inducible expression of a class of small molecule peptides in vivo, is an important part of the body's defense system. Antibacterial peptides not only have broad-spectrum bactericidal ability, but also has anti-fungal, anti-virus, anti-parasites and other biological activity. Antibacterial peptides in vitro anti-inflammatory effects have been studied more, but its anti-inflammatory effect in vivo gradually attracted the attention of scholars. Antibacterial peptides regulate inflammation in many ways, and exert anti-inflammatory effects mainly by inhibiting the growth of biological pro-inflammatory cytokines, regulating the expression of inflammatory-related signaling pathways and their transcription factors, regulating immune activity and neutralizing LPS. In this paper, anti-inflammatory effects of antimicrobial peptides in vivo are reviewed.