发表在Nat Chem Biol上的两篇文章表明,以剪接体为靶标治疗癌症可能是潜在的新方法。FR901464是一种能杀死肿瘤细胞系的天然细菌产物,但作用靶标不明确。Kaidat等发现用FR901464处理的HeLa细胞,产生一个已知的细胞周期抑制剂p27蛋白羧端短截产物,排除了它是降解产物的可能性后, Two articles published in Nat Chem Biol show that the treatment of cancer with spliceosomes may be a potential new approach. FR901464 is a natural bacterial product that kills tumor cell lines but its target of action is not clear. Kaidat et al found that HeLa cells treated with FR901464 produced a known cell cycle inhibitor p27 protein carboxy terminal short product, ruled out the possibility that it is a degradation product,