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在25±0.1℃,1=0.1 mol·L~(-1) KNO_3条件下,在80％(V/V)DMSO—H_2O混合溶剂中,应用pH法测定了甘氨酸,L—缬氨酸,L—丙氨酸,L—脯氨酸,L—丝氨酸和DL—笨丙氨酸等α—氨基酸(缩写为α—AA,记为B配体)的酸离解常数,Zn(Ⅱ)—α—AA二元配合物和锌(Ⅱ)—芬布芬—α—氨基酸三元配合物(芬布芬缩写为Fen记为A配体)的稳定常数。实验发现在logβ_(102)与pK_2~B,logβ_(111)与pK_2~B及logβ_(111)与logβ_(102)三对参数之间均存在良好的直线自由能关系,用△logK_M和△logβ_(111)二个参数描述了三元配合物相对于二元母体配合物的稳定性,讨论了溶剂的性质、配体分子间的疏水作用、堆积作用对配合物稳定性的影响。
The contents of glycine, L-valine, L-valine and L-valine were measured in a mixed solvent of 80% (V / V) DMSO-H 2 at 25 ± 0.1 ℃ and 1 = 0.1 mol·L -1 KNO 3 (Ⅱ) -α-α-amino acids (abbreviated as α-AA, denoted as B ligands) such as alanine, L- proline, L-serine and DL-stupid alanine, AA binary complex and the zinc (II) -fenbufen-alpha-amino acid ternary complex (Fenbufen abbreviated as Fen ligand A). The experimental results showed that there was a good linear free energy relationship between log β 102 and pK 2 B, log β 111 and pK 2 B, log β 111 and log β 102, (111) Two parameters describe the stability of the ternary complex with respect to the binary parent complex. The properties of the solvent, the hydrophobic interaction between the ligand molecules and the stacking effect on the stability of the complex are discussed.