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目的 :对比分析氯胺酮分别与羟丁酸钠、咪达唑仑、异丙酚合用于儿童小手术的静脉麻醉效果。方法 :随机分为氯胺酮 +羟丁酸钠组 33例 ,氯胺酮 +咪达唑仑组 2 7例 ,氯胺酮 +丙泊酚组 30例 ,均观察其围麻醉期心率、血氧饱和度、平均动脉压的变化及苏醒时间、离室时间和苏醒期不良反应等。结果 :氯胺酮 +羟丁酸钠组心率较麻醉前显著减慢 (P <0 0 1) ,而平均动脉压升高 (P <0 0 5 ) ,血氧饱和度无显著改变。氯胺酮 +咪达唑仑组血氧饱和度较麻醉前下降 (P <0 0 5 ) ,心率与平均动脉压基本无变化。氯胺酮 +丙泊酚组麻醉期间呼吸循环基本稳定 ,且与其他两组相比苏醒快 (P <0 0 5 ) ,几乎无苏醒期不良反应 ,离开手术室的时间早于其他两组 (P <0 0 5 )。结论 :儿童小手术应用氯胺酮 +丙泊酚复合麻醉效果确切、安全性高、并发症少
OBJECTIVE: To compare and analyze the effect of ketamine combined with sodium oxybate, midazolam and propofol, respectively, for venous anesthesia in children undergoing minor surgery. Methods: Randomly divided into ketamine + sodium oxybate group 33 cases, ketamine + midazolam group 27 cases, ketamine + propofol group 30 cases, were observed during the perioperative anesthesia heart rate, oxygen saturation, mean arterial Pressure changes and recovery time, room time and recovery period adverse reactions. Results: The heart rate of ketamine + oxybutyrate group was significantly lower than that before anesthesia (P <0.01), while the mean arterial pressure was increased (P <0 05). There was no significant change in the oxygen saturation. The blood oxygen saturation of ketamine + midazolam group was lower than that before anesthesia (P <0.05), and heart rate and mean arterial pressure were almost unchanged. Respiratory circulation was stable during ketamine + propofol anesthesia and recovered faster than the other two groups (P <0 05). There was almost no adverse reactions during the recovery phase, leaving the operating room earlier than the other two groups (P < 0 0 5). Conclusion: The small anesthesia combined with ketamine and propofol in pediatric surgery has definite effect, high safety and few complications