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目的:研究三黄健齿汤联合牙周局部治疗慢性牙周炎的临床疗效,并观察其对炎症因子的影响,为临床诊疗提供依据。方法:选取2015年10月到2016年3月我院收治慢性牙周炎患者130例,按照随机数字表法将患者分为治疗组和对照组,每组65例,对照组给予洁治和龈下刮治、根面平整等,治疗组在对照组的基础上给予三黄健齿汤治疗,比较治疗前和治疗后牙周探诊深度(PD)、牙龈出血指数(BI)、牙龈沟液白介素-1β(IL-1β)、白介素-6(IL-6)水平变化,并比较中医证候评分。结果:治疗后两组PD和BI均显著降低,差异有统计学意义(P<0.05),但两组间比较差异无统计学意义(P>0.05);治疗后两组IL-1β和IL-6均显著降低,且治疗组低于对照组,差异有统计学意义(P<0.05);治疗后两组中医主证候群和次证候评分均显著降低(P<0.05),两组主证候群评分比较差异无统计学意义(P>0.05),治疗组次证候评分显著低于对照组(P<0.05)。结论:三黄健齿汤联合牙周局部治疗对慢性牙周炎具有较好疗效,能有效降低炎症因子,改善次证候评分。
Objective: To study the clinical efficacy of Sanhuang Jiantang Decoction in combination with periodontal local treatment of chronic periodontitis and to observe its effect on inflammatory factors, so as to provide evidence for clinical diagnosis and treatment. Methods: From October 2015 to March 2016, 130 patients with chronic periodontitis were admitted to our hospital. According to the random number table, the patients were divided into treatment group and control group, with 65 cases in each group. The control group was given Jiezhi and gingival The treatment group under the control group was given San Huang Jian Tooth Decoction treatment, compared before and after treatment of periodontal exploration depth (PD), gingival bleeding index (BI), gingival crevicular fluid The levels of interleukin-1β (IL-1β) and interleukin-6 (IL-6) were measured and compared with TCM syndrome scores. Results: After treatment, PD and BI were significantly decreased in both groups (P <0.05), but there was no significant difference between the two groups (P> 0.05). After treatment, the levels of IL-1β and IL- 6 were significantly lower than those in the control group (P <0.05). After treatment, both the main TCM syndromes and the sub-syndrome scores were significantly lower in both groups (P <0.05) There was no significant difference in syndrome score between the two groups (P> 0.05). The score of sub-syndrome in the treatment group was significantly lower than that in the control group (P <0.05). Conclusion: San Huang Jian Tooth Decoction combined with periodontal local treatment of chronic periodontitis has a good effect, can effectively reduce the inflammatory cytokines, improve the sub-syndrome score.