论文部分内容阅读
缓释片剂比普通片剂服用次数少而维持时间长,是为维持血液中有效浓度而设计的一种片剂。求缓释片剂的溶出曲线,对预测服用效果和副作用是重要的。但按片剂特性求得溶出曲线则需作长时间的测定。作者前报曾指出,利用电子计算机可将各种类型缓释片剂的溶出曲线用下式表示,而且,只要测定溶出率前半时间的数据,就可用于决定收敛参数,这样全部溶出过程的溶出曲线便能精确地预测出来。
Sustained-release tablets take less time than regular tablets and stay long, a tablet designed to maintain an effective concentration in the bloodstream. It is important to predict dissolution and side effects of slow release tablets. However, according to the dissolution characteristics of the tablet obtained the curve for a long time to be measured. The author has previously pointed out that the use of computerized dissolution of various types of sustained-release tablets can be expressed by the following formula, and as long as the determination of the dissolution rate of the first half of the data can be used to determine the convergence parameters, so that the dissolution of the whole dissolution process The curve can be accurately predicted.