论文部分内容阅读
位于线粒体中的锰超氧化物歧化酶(manganese superoxide dismutase,MnSOD)可与其他抗氧化酶共同作用清除体内过多的活性氧(ROS),维持机体内氧化还原状态的稳定,保护机体免受过氧化损伤,防止多种疾病的发生。目前众多研究表明,ROS在p53介导的凋亡中发挥着重要作用,ROS可通过多种途径诱导p53的活化,而p53也可与MnSOD相互作用影响ROS的产生,三者关系错综复杂,与肿瘤的发生发展和凋亡关系均十分密切,本文就三者之间关系及对肿瘤和调亡的影响予以简要综述。
Manganese superoxide dismutase (MnSOD), located in mitochondria, works together with other antioxidant enzymes to remove excessive reactive oxygen species (ROS) in the body and maintain the body’s redox state stability and protect the body from over Oxidative damage, to prevent the occurrence of a variety of diseases. At present, many researches show that ROS plays an important role in p53-mediated apoptosis. ROS can induce the activation of p53 through a variety of pathways. However, p53 also interacts with MnSOD to affect the production of ROS. The relationship between ROS and tumor The occurrence and development and apoptosis are very close, this article on the relationship between the three and the impact on tumor and apoptosis are briefly reviewed.