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目的探讨脂质代谢与糖尿病视网膜病变之间的关系。方法检测１６８例糖尿病病人血清中的总胆固醇（ＣＨ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、载脂蛋白Ａ１（ＡｐｏＡ１）、载脂蛋白Ｂ１００（ＡｐｏＢ１００）和脂蛋白（ａ）［Ｌｐ（ａ）］；并同时观察这些病人的视网膜情况。结果伴有糖尿病视网膜病变的病人血清中的总胆固醇、ＬＤＬ－Ｃ和Ｌｐ（ａ）较不伴有糖尿病视网膜病变的病人明显增高，而ＨＤＬ－Ｃ、ＡｐｏＡ１和ＡｐｏＡ１／ＡｐｏＢ１００比例则较无糖尿病视网膜病变的病人明显降低。经Ｌｏｇｉｓｔｉｃ回归分析，总胆固醇、ＨＤＬ－Ｃ和ＡｐｏＡ１／ＡｐｏＢ１００作为独立的因素仍然与糖尿病视网膜病变相关。结论脂质代谢的异常，可能是糖尿病视网膜病变发生和加重的重要因素。
Objective To investigate the relationship between lipid metabolism and diabetic retinopathy. Methods Serum levels of total cholesterol (CH), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein A1 ), Apolipoprotein B100 (ApoB100) and lipoprotein (a) [Lp (a)]. The retina condition was also observed in these patients. Results Serum total cholesterol, LDL-C and Lp (a) in patients with diabetic retinopathy were significantly higher than those without diabetic retinopathy, while the ratios of HDL-C, ApoA1 and ApoA1 / ApoB100 were significantly higher than those without diabetic retinopathy Lesion patients significantly reduced. Logistic regression analysis showed that total cholesterol, HDL-C and ApoA1 / ApoB100 were still associated with diabetic retinopathy as independent factors. Conclusion Abnormal lipid metabolism may be an important factor in the occurrence and aggravation of diabetic retinopathy.