采用D-氨基半乳糖(简称D-gal)作为肝毒剂,建立急性肝功能衰竭的动物模型,目前国内外较多采用的动物是大白鼠,但家兔在当前医学科研中仍是常用的实验动物之一,有关D-gal在家兔所致的急性实验性肝功能衰竭时肝损害的病理组织学改变资料,国内尚未见有报道。为了进一步研究和利用家兔作为D-gal诱发实验性肝损害模型提供形态学资料,我们进行了以下实验。材料与方法一、实验动物: 健康雄性杂种大白兔28只,体重2～3公斤,5～6个月兔龄,实验前须稳定 D-galactosamine (referred to as D-gal) as a hepatotoxic agent, the establishment of animal models of acute liver failure, the current domestic and foreign animals are more used rats, but rabbits in the current medical research is still commonly used in experiments Animal, one of the D-gal in rabbit acute liver failure caused by experimental liver histopathological changes in the information has not been reported in the country. In order to further study and make use of rabbit morphology as a D-gal-induced experimental liver injury model, we performed the following experiment. Materials and methods First, the experimental animals: healthy male hybrid white rabbits 28, weighing 2 to 3 kg, 5 to 6 months old rabbit, stable before the experiment