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对12只Wistar大鼠进行透射电镜观察,发现大剂量维生素D_3主要作用於肾曲管上皮及下方的基底膜。其中以肾曲管上皮内线粒体的病变最为突出,表现为线粒体内有大量电子致密颗粒——磷酸钙沉积以及线粒体肿胀等。磷酸钙沉着是线粒体损伤的早期征象,随后发生线粒体肿胀。亦可见层状电子致密细颗粒状沉积物沿肾小管基底膜排列。病变的程度同给药时间的长短和Wistar大鼠的年龄(乳鼠或成鼠)无明显关系。
Transmission electron microscopy was performed on 12 Wistar rats. It was found that large doses of vitamin D3 mainly acted on the renal canalicular epithelium and underlying basement membrane. Among them, the lesions of mitochondria in the epithelium of the renal canal were the most prominent, with a large number of electron dense particles in the mitochondrion - calcium phosphate deposition and mitochondrial swelling. Calcium phosphate deposition is an early sign of mitochondrial damage, followed by mitochondrial swelling. It can also be seen that the layered electron dense fine-grained deposits are arranged along the basement membrane of the renal tubule. The extent of the lesion was not significantly related to the length of the administration and the age of the Wistar rats (neonatal or adult mice).