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血管生成是指从已存在的血管中以出芽的方式生成新血管的过程。血管内皮细胞生长因子(VEGF)能促进生理和病理的血管生成。VEGF有两个主要的酪氨酸激酶受体VEGFR1(Flt1)和VEGFR2(KDR/Flk1)。VEGF的生物学效应主要是通过VEGFR2实现的,多种信号蛋白的激活均与VEGF的信号转导有关,涉及促内皮细胞生存、增殖、迁移,促进血管渗透增加,促进NO合成及释放等多项生物学功能。
Angiogenesis refers to the process of sprouting new blood vessels from an existing blood vessel. Vascular endothelial growth factor (VEGF) promotes both physiological and pathological angiogenesis. VEGF has two major tyrosine kinase receptors, VEGFR1 (Flt1) and VEGFR2 (KDR / Flk1). The biological effects of VEGF are mainly achieved through VEGFR2. The activation of various signaling proteins is related to the signal transduction of VEGF, which involves the promotion of the survival, proliferation, migration of endothelial cells, the increase of vascular permeability, the promotion of NO synthesis and release biological functions.