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目的:对RhD新生儿溶血病导致的D抗原假阴性进行鉴定。方法:采用放散试验、抗人球蛋白等试验对母亲和患儿血清抗体及D抗原进行鉴定。结果:患儿血型为O型CcDee,母亲血型为O型ccdee,新生儿直接抗人球蛋白试验阳性,游离试验和放散试验均检测出抗-D抗体,母亲体内检出抗-D抗体。结论:当患儿直接抗人球蛋白试验强阳性,D抗原检测阴性,其母体内存在抗-D抗体时应排除D抗原完全遮断引起的假阴性。
Objective: To identify the false negative of D antigen caused by RhD hemolytic disease. Methods: The blood test and anti-human globulin test were used to identify the serum antibody and D antigen of mother and children. Results: The blood type of children was O type CcDee, the blood type of the mother was O type ccdee, the newborn’s direct anti-human globulin test was positive, the anti-D antibody was detected both in the free test and the discharge test, and the anti-D antibody was detected in the mother. CONCLUSIONS: When the direct anti-human globulin test in children is strongly positive and the D antigen test is negative, the presence of anti-D antibody in the mother should exclude false negatives caused by complete occlusion of the D antigen.