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将一种前列腺素E_1类似物米索前列醇(misoprostol)制成双层漂浮胶囊延长胃潴留时间(GRT),以治疗胃及十二指肠溃疡。该胶囊一层为漂浮层,由羟丙甲基纤维素(HPMC)、methocel K4M 80.0％、乳糖14.96％、硬脂酸镁5.0％和硅胶2000.04％组成。高浓度、高粘度HPMC形成凝胶,阻滞水进入,利于漂浮且不易破裂。胶囊的漂浮力值以浸于pH 1.2和6.0的介质中胶囊的重量来表示,若重量大且为正,表明浮力好,若为负则下沉。增加HPMC量可提高漂浮力,如
A prostaglandin E 1 analogue, misoprostol, is made into a double-layered floating capsule to prolong gastric retention (GRT) to treat gastric and duodenal ulcers. The capsule is a floating layer consisting of 80.0% hydroxypropyl methylcellulose (HPMC), methocel K4M, 14.96% lactose, 5.0% magnesium stearate and 2000.04% silica gel. High concentration, high viscosity HPMC form a gel, blocking the water into, conducive to floating and not easy to rupture. The buoyancy value of the capsule is expressed as the weight of the capsule immersed in a medium at pH 1.2 and 6.0, and if the weight is large and positive, it indicates good buoyancy and if negative, it sinks. Increasing the amount of HPMC increases the buoyancy force, for example