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合成7α,18-二甲基-19-去甲基-甾体物的关键中间体10a是通过从3a与4的缩合物5经氢化、环合、再氢化而得到.同样地可获得7β,18-二甲基雌甾二醇衍生物10b即:6→7b→9b→10b.
The key intermediate 10a for the synthesis of the 7α, 18-dimethyl-19-nor-methyl-steroid is obtained by hydrogenation, cyclization and rehydrogenation of the condensate 5 from 3a and 4. Likewise 7β, The 18-dimethyleesterol derivative 10b is: 6 → 7b → 9b → 10b.