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目的分析并总结耐药肺结核病患者的临床特点,为临床选择合理有效的治疗方案提供理论依据。方法病例来源于本院2016年1月-2017年1月感染科收治的100例耐药肺结核病患者,按照年龄划分组别,青年组(n=38)、中年组(n=35)、老年组(n=27),分析三组患者的临床资料,总结其耐药特征和治疗后的疗效。结果就患者耐药情况而言,以原发性耐药所占比例最高,与获得性耐药比较差异显著(P<0.05);青年组原发性耐药率所占比例最高,与其他组别比较差异显著(P<0.05);治疗期间,患者可能出现肝功能指标异常。结论临床应加强不同年龄阶段结核病患者的耐药检测,一旦出现耐药肺结核临床治疗较棘手,且治疗期间不良反应多,患者疾病转归差。
Objective To analyze and summarize the clinical features of patients with drug-resistant pulmonary tuberculosis and provide a theoretical basis for clinical choice of rational and effective treatment programs. Methods The patients were from 100 patients with drug-resistant pulmonary tuberculosis who were admitted to our department from January 2016 to January 2017. The patients in the youth group (n = 38), the middle-aged group (n = 35) The elderly group (n = 27) analyzed the clinical data of three groups of patients and summarized the characteristics of their resistance and the therapeutic effect after treatment. Results In terms of drug resistance of patients, the proportion of primary drug resistance was the highest and that of acquired drug resistance was significantly higher than that of acquired drug resistance (P <0.05). The proportion of primary drug resistance was the highest in youth group, The difference was significant (P <0.05). During the treatment, the patient may have abnormal liver function. Conclusions The drug resistance test should be strengthened in patients with tuberculosis in different age groups. Once the clinical treatment of resistant tuberculosis is more difficult and the adverse reactions are more during the treatment, the patient’s disease is worsened.