从食物蛋白结合钴胺素中释出钴胺素需要酸和胃蛋白酶。胃酸缺乏导致钴胺素吸收不良是钴胺素缺乏的熟知原因之一。为此作者在奥美拉唑治疗时和之前用一种食物Schilling试验测定蛋白结合钴胺素吸收。12例食管炎(3～4级)患者(平均年龄43岁,范围31～72岁,6例男性)开始每日40mg奥美拉唑。还测定10例健康志愿者的钴胺素吸收。 Acid and pepsin are required for the release of cobalamin from food protein-bound cobalamin. One of the well-known causes of cobalamin deficiency is the lack of achlorhydria, leading to malabsorption of cobalamin. For this reason, the authors measured protein-bound cobalamin absorption with and before a food-based Schilling test on and before omeprazole treatment. 12 patients with esophagitis (grade 3-4) (mean age 43 years, range, 31-72 years, 6 males) started daily 40 mg omeprazole. Cobalt amine absorption was also measured in 10 healthy volunteers.