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从雌二醇-17β出发,经过Loudon邻羟化等反应,合成了2-甲氧基炔雌醇等雌甾化合物。对各步反应的条件及方法作出了改进。本合成工作同前报所合成的2-羟基炔雌醇3-甲醚的结构形成互相验证。
Starting from estradiol-17β, estradiol such as 2-methoxyethynyl estradiol was synthesized via Loudon o-hydroxylation. The conditions and methods of each step reaction have been improved. The synthesis work with the previous synthesis of 2-hydroxy-ethinylestradiol 3-methyl-ether structure to verify each other.