论文部分内容阅读
Albert首先使用“前体-药物”(Pro-drug)一词来表达它是经过生物转化才具有药理作用的化合物。前体-药物方法并不新,早在19世纪后期被合成的六亚甲四胺(Methenamine)(Ⅰ)及阿司匹林(Ⅱ)就是甲醛及水杨酸生物转化衍生物的例子。
Albert first used the term “Pro-drug” to express that it is a biologically transformed compound that has a pharmacological effect. The precursor-drug approach is not new. Methenamine (I) and aspirin (II) were synthesized as early as the late 19th century as examples of biotransformed derivatives of formaldehyde and salicylic acid.