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目的:探讨尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)活性检测在良性前列腺增生患者肾功能损害判断中的意义。方法:将东莞市茶山医院收治的76例良性前列腺增生患者为观察组。选择76例正常健康者为对照组。比较两组尿液NAG及血β2微球蛋白水平的差异,同时评价观察组患者治疗前后尿液NAG水平的变化,分析尿液NAG与最大尿流率的关系。结果:观察组患者尿液NAG及血β2微球蛋白水平显著高于对照组,差异具有统计学意义(P<0.05);治疗后3月良性前列腺增生患者尿液NAG水平显著低于治疗前,差异具有统计学意义(P<0.05);良性前列腺增生患者尿液NAG水平与最大尿流率呈明显的正相关(P<0.01);观察组患者BUN、CR水平稍高于对照组,差异无统计学意义(P>0.05),均属于正常范围。结论:尿液NAG活性检测是良性前列腺增生患者肾功能损害有效的监测指标。
Objective: To investigate the significance of urinary N-acetyl-β-D-glucosaminidase (NAG) activity in judging renal dysfunction in patients with benign prostatic hyperplasia. Methods: 76 cases of benign prostatic hyperplasia patients admitted to Dasan Hospital of Dongguan City were observed. 76 healthy controls were selected as control group. The differences of urinary NAG and β2 microglobulin levels between the two groups were compared. Urinary NAG level in the observation group before and after treatment was also evaluated. The relationship between urine NAG and maximal uroflow rate was analyzed. Results: Urine NAG and blood β2-microglobulin levels in observation group were significantly higher than those in control group (P <0.05). Urine NAG levels in patients with benign prostatic hyperplasia at 3 months after treatment were significantly lower than those before treatment, (P <0.05). There was a significant positive correlation between urinary NAG level and maximum uroflow rate in patients with benign prostatic hyperplasia (P <0.01). The levels of BUN and CR in the observation group were slightly higher than those in the control group, with no difference Statistical significance (P> 0.05), all belong to the normal range. Conclusion: Urinary NAG activity is an effective monitoring indicator of renal dysfunction in patients with benign prostatic hyperplasia.