We report a case of a 61-year-old man who presentedwith fatigue,abdominal pain and hepatomegaly.Computedtomography (CT) of the abdomen showed hepatomegalyand multiple hepatic lesions highly suggestive of metastaticdiseases.Due to the endoscopic finding of colon ulcer,coloncancer with liver metastases was suspected.Biochemicallya slight increase of transaminases,alkaline phosphataseand gammaglutamyl transpeptidase were present;α-fetoprotein,carcinoembryogenic antigen and carbohydrate19-9 antigen serum levels were normal.Laboratory andinstrumental investigations,including colon and liver biopsiesrevealed no signs of malignancy.In the light of spontaneousimprovement of symptoms and CT findings,his personalhistory was revaluated revealing direct contact with pigsand their tissues.Diagnosis of leptospirosis was consideredand confirmed by detection of an elevated titer of antibodiesto leptospira.After two mo,biochemical data,CT andcolonoscopy were totally normal. We report a case of a 61-year-old man who presented with fatigue, abdominal pain and hepatomegaly. Computed tomography (of CT) of the abdomen showed hepatomegaly and multiple hepatic lesions highly suggestive of metastatic disease. End to endoscopic finding of colon ulcer, coloncancer with liver metastases were reduced. biochemically slight increase of transaminases, alkaline phosphatase and gammaglutamyl transpeptidase were present; α-fetoprotein, carcinoembryogenic antigen and carbohydrate19-9 antigen serum levels were normal. Laboratory and experimental investigations, including colon and liver biopsiesrevealed no signs of malignancy. in the light of spontaneousimprovement of symptoms and CT findings, his personalhistory was revaluated revealing direct contact with pigsand their tissues. Diagnostic of leptospirosis was consideredand confirmed by detection of an elevated titer of antibodiesto leptospira. After two mo, biochemical data, CT and coloscopy were totally normal.