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作者对15例经内镜及X线证实有直径大于5mm溃疡面的单纯十二指肠溃疡患者(DUP)测定了血浆神经介质和皮质醇,以研究DUP于愈合和复发期间这些物质的情况。15例中男性9例,女性6例,平均年龄39岁(21～53岁)。治疗于首次内镜确诊之6天内开始,对患者和对照者给抗酸剂共18周,受试者都无精神病史,并接受精神分析和肌注可乐宁试验。DUP与正常对照者配对于治疗前及治疗后每6周测定去甲肾上腺素(NA)、肾上腺素(A)、多巴胺(DA)、血小板5-羟色胺(pS)、血浆游离5-羟色胺(fS)和皮质醇(CRT)。治疗开始及每二周随访一次,以了解症状和副作用。治疗后6、12,18周各作一次内镜及X线检查,溃疡面完全为上皮所覆盖为溃疡愈合。治疗6周后的15例DUP中12例(80％)溃疡愈
The authors measured plasma neurotransmitter and cortisol in 15 patients with duodenal ulcer (DUP), confirmed by endoscopy and X-ray examination to be larger than 5 mm in diameter, to study the effects of DUP on these substances during healing and relapse. Among the 15 cases, 9 were males and 6 were females, with an average age of 39 years (21-53 years). The treatment started within 6 days of the first endoscopic diagnosis, antacids were administered to both patients and controls for 18 weeks, and all subjects had no history of psychosis and were subjected to psychoanalysis and intramuscular cortisol tests. DUP and normal controls were matched to norepinephrine (NA), epinephrine (A), dopamine (DA), platelet serotonin (pS), plasma free 5-hydroxytryptamine ) And cortisol (CRT). The treatment is started and followed up every two weeks to understand the symptoms and side effects. 6,12,18 weeks after treatment for each endoscopy and X-ray examination, ulcer surface completely covered by epithelial healing of ulcers. Twelve of the 15 DUPs (80%) cured the ulcer after 6 weeks of treatment