糖尿病已成为致残率、死亡率仅次于肿瘤和心血管病的第三大疾病,全世界约有1.35亿人深受其害[1]。糖尿病患者由于胰岛素相对或完全不足导致葡萄糖利用低下,长期处于高血糖状态,引发各种慢性并发症,糖尿病性神经病变是并发症之一。但目前大量研究的是末梢神经病变,而糖尿病也可 Diabetes has become the third most common cause of morbidity and mortality after cancer and cardiovascular disease, affecting about 135 million people worldwide [1]. Diabetes due to the relative or complete lack of insulin led to low glucose utilization, long-term high blood sugar, triggering a variety of chronic complications, diabetic neuropathy is one of the complications. However, a large number of studies are currently peripheral neuropathy, and diabetes can be