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[目的]探讨狼疮肾炎(LN)患者外周免疫损伤细胞因子的表达及调控机制.[方法]56 例 LN患者设为观察组.根据系统性红斑狼疮(SLE)疾病活动性量表测定结果将患者分为 LN活动组(≥10 分)与 LN稳定组(＜10分).选择同期入院健康体检者 34例为对照组.检测比较各组血 HMGB1、抗 C1q抗体、抗 AnuA抗体及CD3+、CD4+、CD8+、CD4+／CD8+水平;对血 HMGB1、抗C1q抗体、抗AnuA抗体水平与T淋巴细胞水平进行相关性分析.[结果]观察组中LN活动组 HMGB1、抗C1q抗体、抗AnuA抗体水平均高于LN稳定组(P ＜0.05);LN活动组CD3+、CD4+及CD4+／CD8+水平均低于,CD8+水平高于 LN稳定组(P ＜0.05);相关性分析结果表明:LN患者 HMGB1、抗C1q、抗 AnuA抗体与CD3+、CD4+及 CD4+／CD8+呈负相关性(P ＜0.05);与 CD8+呈正相关性(P ＜0.05).[结论]血 HMGB1、抗C1q抗体、抗 AnuA抗体在 LN患者中呈高表达,且与 T淋巴细胞水平具有相关性,能参与 LN的发生、发展.“,”[Objective]To investigate cytokines＇expression and regulation of peripheral immune injury in patients with lupus nephritis (LN).[Methods]A total of 56 patients with LN were selected as the observation group.LN patients were divided into the active group (≥10 points)and the stable group (＜10 points)based on the results of the measurements using systemic lupus erythematosus (SLE)Disease Activity Scale.At the same time period,34 healthy volunteers who admitted to our hospital for physical examination were enrolled as the control group.The levels of HMGB1,anti C1q antibody,anti AnuA antibody,CD3+,CD4+,CD8+ and ratio of CD4+／CD8+ in each group were determined.The correlations of blood HMGB1,anti C1q and anti AnuA level with T lymphocyte level were analyzed by SPSS Pearson analysis software.[Results]The levels of HMGB1,anti C1q antibody and anti AnuA antibody in LN active subgroup were higher than those in LN stable subgroup (P ＜0.05).The levels of CD3+,CD4+ and CD4+／CD8+ in LN active subgroup were lower than those in LN stable subgroup in observation group.The stable group (P＜0.05),while the CD8+level in the active subgroup was higher than that in the stable subgroup (P＜0.05).SPSS Pearson correlation analysis showed that HMGB1,anti C1q and anti AnuA antibodies were negatively correlated with CD3+,CD4+ and CD4+／CD8+ in LN patients (P＜0.05),while they were positively correlated with CD8+ level (P＜0.05).[Conclusion]Blood HMGB1,anti C1q antibody and anti AnuA antibody are highly expressed in LN patients.HMGB1,anti C1q antibody and anti AnuA antibody have a correlation with T lymphocyte levels,which can participate in the occurrence and development of lupus nephritis.